Immunohistochemical Detection ofNRASQ61R Mutation in Diverse Tumor Types

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Immunohistochemical Detection of NRASQ61R Mutation in Diverse Tumor Types.

OBJECTIVES Testing for NRAS mutation at codon Q61 is of therapeutic, prognostic, and diagnostic importance for metastatic melanoma, thyroid carcinoma, and colorectal carcinoma. Immunohistochemistry for NRASQ61R, the most common NRAS mutation, offers several practical advantages over current molecular diagnostic techniques. METHODS We investigated the sensitivity and specificity of NRASQ61R in...

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ژورنال

عنوان ژورنال: American Journal of Clinical Pathology

سال: 2015

ISSN: 0002-9173,1943-7722

DOI: 10.1093/ajcp/aqv015